Phenylboronic Acid → 5-Phenylpyrimidine-2-carboxylic acid

HRID 1784747Notes

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1.[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([C:2]2[CH:3]=[N:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 164629705-Bromopyrimidine-2-carboxylic acid

Product 1

HCID 6082555-Phenylpyrimidine-2-carboxylic acid

Procedure

Conducting the operations similar to those of Production Example 14 using 5-bromopyrimidine-2-carboxylic acid and phenylboronic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record: ord-c5a303d6deb74c0b93190cb64720a986
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504412B2

Reaction notes

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