HCID 23120553, compound → HCID 23120587, compound

HRID 1784750Notes

Reaction equation

HRID 1784750 reaction equation
[BrH:1].[CH:2]([C:5]1[N:6]=[C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]2[CH:16]=1)([CH3:4])[CH3:3].[H][H]>[Pd].CO>[BrH:1].[NH2:13][C:10]1[CH:11]=[CH:12][C:7]2[N:8]([CH:16]=[C:5]([CH:2]([CH3:4])[CH3:3])[N:6]=2)[CH:9]=1

Participants

5

Reactant 2

HCID 23120553HCID 23120553, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23120587HCID 23120587, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a methanol solution (20 ml) containing 2-isopropyl-6-nitroimidazo[1,2-a]pyridine hydrobromide (280 mg), 10% palladium-on-carbon (30 mg) was added, and inside the reaction system was substituted with hydrogen, followed by an hour's stirring at room temperature. The reaction liquid was filtered through Celite™. Concentrating the filtrate under reduced pressure, crude 6-amino-2-isopropylimidazo[1,2-a]pyridine hydrobromide (250 mg) was obtained.

Workup

  1. additionwas added
  2. waitfollowed by an hour
  3. customThe reaction liquid
  4. filtrationwas filtered through Celite™
  5. concentrationConcentrating the filtrate under reduced pressure

Sources & evidence

ORD record
ord-77e5cd59cb334e53be89678974c2cb6b
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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