4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → N-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxamide
Reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][N:5]2[C:13]=1[CH3:14].[F:15][C:16]([F:33])([F:32])[C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([C:29](O)=[O:30])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([NH:10][C:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20]4[CH:21]=[CH:22][C:17]([C:16]([F:15])([F:32])[F:33])=[CH:18][CH:19]=4)=[CH:28][CH:27]=3)=[O:30])=[CH:6][N:5]2[C:13]=1[CH3:14]Participants
3
Procedure
Conducting the operations similar to those of Example 1 using 2,3-dimethyl-6-nitroimidazo[1,2-a]pyridine and 4′-(trifluoromethyl)-[1,1′-biphenyl]-4-carboxylic acid, the title compound was obtained as white solid.
Sources & evidence
- ORD record
- ord-a69300b5d7a74e068179e9b4bf9f57aa
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504412B2
Reaction notes
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