Hydrogen chloride-ethyl acetate → HCID 23120539, compound

HRID 1784756Notes

Reaction equation

HRID 1784756 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]([F:35])([F:34])[C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=2)=[N:23][CH:24]=1.[ClH:36].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:36].[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:31](=[O:32])[C:28]4[CH:27]=[CH:26][C:25]([C:22]5[CH:21]=[CH:20][C:19]([C:18]([F:35])([F:17])[F:34])=[CH:24][N:23]=5)=[CH:30][CH:29]=4)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 21866389Hydrogen chloride-ethyl acetateHCID 227306714-[5-(Trifluoromethyl)pyridin-2-yl]benzoic acidHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 23120539HCID 23120539, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4-[5-(trifluoromethyl)-2-pyridyl]benzenecarboxylic acid. The resulting solid was dissolved in ethyl acetate, followed by addition of 4N hydrochloric acid-ethyl acetate solution and concentration under reduced pressure. The title compound was obtained as white solid.

Sources & evidence

ORD record
ord-42e9fc4380bc4881991ed9fcabf600a7
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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