Hydrogen chloride-ethyl acetate → HCID 23120585, compound

HRID 1784757Notes

Reaction equation

HRID 1784757 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]([F:35])([F:34])[C:19]1[N:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1.[ClH:36].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:36].[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:31](=[O:32])[C:28]4[CH:27]=[CH:26][C:25]([C:22]5[CH:23]=[N:24][C:19]([C:18]([F:35])([F:17])[F:34])=[CH:20][CH:21]=5)=[CH:30][CH:29]=4)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 21866389Hydrogen chloride-ethyl acetateHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridineHCID 231205374-[6-(Trifluoromethyl)pyridin-3-yl]benzoic acid

Product 1

HCID 23120585HCID 23120585, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4-[6-(trifluoromethyl)-3-pyridyl]benzenecarboxylic acid. The resulting solid was dissolved in ethyl acetate, followed by addition of 4N hydrochloric acid-ethyl acetate solution and concentration under reduced pressure. The title compound was obtained as white solid.

Sources & evidence

ORD record
ord-471546c6ac364d7c96d3d1386dc55f67
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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