Acetic Acid → Tert-butyl 3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

HRID 178476Notes

Reaction equation

HRID 178476 reaction equation
[CH3:24][C:25](=[O:26])[OH:27].[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[cH:8][cH:9][c:10]2[C:11]1=[CH:16][N:15]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:13][CH2:12]1.[Pt:28](=[O:29])=[O:30]>>[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[cH:8][cH:9][c:10]2[CH:11]1[CH2:12][CH2:13][CH2:14][N:15]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:16]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 345198Adams' catalystHCID 58529940tert-butyl 5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 58529279Tert-butyl 3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7238c76083274efba5223fdcf307ea18
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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