Hydrogen chloride-ethyl acetate → HCID 23120551, compound

HRID 1784761Notes

Reaction equation

HRID 1784761 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]1[CH:19]=[C:20]([C:24]2[CH:25]=[N:26][C:27]([C:30](O)=[O:31])=[N:28][CH:29]=2)[CH:21]=[CH:22][CH:23]=1.[ClH:33].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:33].[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:30]([C:27]4[N:26]=[CH:25][C:24]([C:20]5[CH:21]=[CH:22][CH:23]=[C:18]([F:17])[CH:19]=5)=[CH:29][N:28]=4)=[O:31])=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23111883HCID 23111883, compoundHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 23120551HCID 23120551, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 5-(3-fluorophenyl)-2-pyrimidinecarboxylic acid. The resulting solid was dissolved in ethyl acetate, followed by addition of 4N hydrochloric acid-ethyl acetate solution and concentration under reduced pressure. The title compound was obtained as white solid.

Sources & evidence

ORD record
ord-a7fa36e4a61548c682686ce652ecc4d0
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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