4-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid → N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[5-(difluoromethoxy)-2-pyridyl] benzamide

HRID 1784769Notes

Reaction equation

HRID 1784769 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][CH:18]([F:35])[O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32](O)=[O:33])=[CH:28][CH:27]=2)=[N:24][CH:25]=1>>[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:32](=[O:33])[C:29]4[CH:28]=[CH:27][C:26]([C:23]5[CH:22]=[CH:21][C:20]([O:19][CH:18]([F:35])[F:17])=[CH:25][N:24]=5)=[CH:31][CH:30]=4)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 231205134-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acidHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 23120584N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[5-(difluoromethoxy)-2-pyridyl] benzamide

Procedure

Conducting the operations similar to those of Example 1 using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4-[5-(difluoromethoxy)-2-pyridyl]benzenecarboxylic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-cee137feb6da4ccf9328aa7dec8e873c
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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