2-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine → N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxamide

HRID 1784771Notes

Reaction equation

HRID 1784771 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]1[CH:19]=[C:20]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)[CH:21]=[CH:22][C:23]=1[C:24](O)=[O:25]>>[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:24]([C:23]4[CH:22]=[CH:21][C:20]([C:27]5[CH:32]=[CH:31][C:30]([C:33]([F:34])([F:35])[F:36])=[CH:29][CH:28]=5)=[CH:19][C:18]=4[F:17])=[O:25])=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridineHCID 231205273-Fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 23120536N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxamide

Procedure

Conducting the operations similar to those of Example 1 using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 3-fluoro-4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-b566a84903c24897bebab23fb36e3eff
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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