4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → N-(2-cyclopropylimidazo[1,2-a]pyridin-6-yl)-4''-(trifluoromethyl)biphenyl-4-carboxamide

HRID 1784778Notes

Reaction equation

HRID 1784778 reaction equation
Br.[CH:2]1([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]3[CH:16]=2)[CH2:4][CH2:3]1.[F:17][C:18]([F:35])([F:34])[C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1>>[CH:2]1([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][C:10]([NH:13][C:31]([C:28]4[CH:27]=[CH:26][C:25]([C:22]5[CH:23]=[CH:24][C:19]([C:18]([F:17])([F:34])[F:35])=[CH:20][CH:21]=5)=[CH:30][CH:29]=4)=[O:32])=[CH:9][N:8]3[CH:16]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 27827194'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acidHCID 231205172-Cyclopropyl-6-nitroimidazo[1,2-a]pyridine hydrobromide

Product 1

HCID 23120576N-(2-cyclopropylimidazo[1,2-a]pyridin-6-yl)-4''-(trifluoromethyl)biphenyl-4-carboxamide

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-6-nitroimidazo[1,2-a]pyridine hydrobromide and 4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid, to provide N-(2-cyclopropylimidazo[1,2-a]pyridin-6-yl)-4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxamide as white solid.

Sources & evidence

ORD record
ord-c68a44aad67a41719d3f49522f7f6d59
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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