Potassium cyanate → HCID 135828228, compound

HRID 1784907Notes

Reaction equation

HRID 1784907 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:20][CH2:21][NH2:22])[N:3]=1.[O-:23][C:24]#[N:25].[K+]>Cl.CO>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:20][CH2:21][NH:22][C:24]([NH2:25])=[O:23])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Participants

5

Reactant 2

HCID 11378442Potassium cyanateHCID 135828224HCID 135828224, compound

Product 1

HCID 135828228HCID 135828228, compound

Reagents, catalysts & solvents 2

HCID 887MethanolCatalystHCID 313Hydrochloric AcidSolvent

Conditions

Temperature
50 °C

Procedure

31.1 mg (0.1 mmol) of 2-amino-6-[(2-aminoethyl)sulfanyl]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile are suspended in 0.91 ml of 1N HCl, and 8.1 mg (0.1 mmol) of potassium cyanate are added. After the addition of a few drops of methanol, the mixture is stirred at 50° C. for a total of 10 hours. The crystals are filtered off with suction and washed with water and ether.

Workup

  1. filtrationThe crystals are filtered off with suction
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-8a1fad36eb70425982c51764c2b086a9
Source dataset
uspto-grants-2009_03
Patent number
US07504421B2

Reaction notes

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