3-Methoxy-4-methylbenzaldehyde → 3-(3-Methoxy-4-methylphenyl)acrylonitrile

HRID 1784947Notes

Reaction equation

HRID 1784947 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[CH3:11])[CH:6]=O.[C:12]([CH2:14]P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)#[N:13]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:14][C:12]#[N:13])[CH:8]=[CH:9][C:10]=1[CH3:11]

Participants

3

Reactant 2

HCID 47150953-Methoxy-4-methylbenzaldehydeHCID 178511462HCID 178511462, compound

Product 1

HCID 689590123-(3-Methoxy-4-methylphenyl)acrylonitrileYield 77%

Procedure

Wittig reaction of 3-methoxy-4-methylbenzaldehyde with cyanomethyl triphenylphosphorane gave 3-(3-methoxy-4-methylphenyl)acrylonitrile in 77% yield which was further transformed to 3-(3-methoxy-4-methylphenyl)propan-1-amine using the above described procedures.

Sources & evidence

ORD record
ord-a5fc16ce1d4c41b2a9a42a400362c159
Source dataset
uspto-grants-2009_03
Patent number
US07504420B2

Reaction notes

Loading…