Sodium Hydroxide → HCID 67531156, compound

HRID 17850Notes

Reaction equation

HRID 17850 reaction equation
[CH:1]1([N:4]2[C:9]3[CH:10]=[CH:11][C:12]([C:14]([O:16]C)=[O:15])=[CH:13][C:8]=3[S:7](=[O:19])(=[O:18])[NH:6][CH2:5]2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO.O>[C:14]([C:12]1[CH:11]=[CH:10][C:9]2[N:4]([CH:1]3[CH2:2][CH2:3]3)[CH2:5][NH:6][S:7](=[O:19])(=[O:18])[C:8]=2[CH:13]=1)([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 675298324-cyclopropyl-3,4-dihydro-7-methoxycarbonyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 67531156HCID 67531156, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
40 °C

Procedure

A solution of the compound of Example 77 (3.5 mmol) in a mixture of methanol/water 1/1 (100 mL) containing NaOH (0.5 g) is heated at 40° C. for 3 hours. The methanol is then removed by distillation under reduced pressure and the resulting aqueous solution is adjusted to pH 2 by adding 6N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

Workup

  1. customThe methanol is then removed by distillation under reduced pressure
  2. additionby adding 6N HCl
  3. customThe precipitate obtained
  4. filtrationis collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-803120676e904e36964df778443c3ed2
Source dataset
uspto-grants-2010_06
Patent number
US07741320B2

Reaction notes

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