反应详情

温度

40 °C

A solution of the compound of Example 77 (3.5 mmol) in a mixture of methanol/water 1/1 (100 mL) containing NaOH (0.5 g) is heated at 40° C. for 3 hours. The methanol is then removed by distillation under reduced pressure and the resulting aqueous solution is adjusted to pH 2 by adding 6N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

1. customThe methanol is then removed by distillation under reduced pressure
2. additionby adding 6N HCl
3. customThe precipitate obtained
4. filtrationis collected by filtration
5. washwashed with water
6. customdried