HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 17850Generated: October 28, 2026
Sodium Hydroxide → HCID 67531156, compound
https://huagongshe.com/reaction/17850
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-cyclopropyl-3,4-dihydro-7-methoxycarbonyl-2H-1,2,4-benzothiadiazine 1,1-dioxide | HCID 67529832 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 67531156 | HCID 67531156 | — |
Reaction Steps
A solution of the compound of Example 77 (3.5 mmol) in a mixture of methanol/water 1/1 (100 mL) containing NaOH (0.5 g) is heated at 40° C. for 3 hours. The methanol is then removed by distillation under reduced pressure and the resulting aqueous solution is adjusted to pH 2 by adding 6N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07741320B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-803120676e904e36964df778443c3ed2 |
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| Source note | uspto-grants-2010_06 |
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