4-Fluorophenylboronic acid → benzyl 4-ethyl-2-formyl-5-pyridin4-yl-1H-pyrrole-3-carboxylate
Reaction equation
[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1I)[CH3:2].FC1C=CC(B(O)O)=CC=1.[N:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1[C:34]1[CH:35]=[CH:36][N:31]=[CH:32][CH:33]=1)[CH3:2]Participants
4
Procedure
Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with pyridin-4-ylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C20H19N2O3 (M+H): 335.1390. Found 335.1402
Sources & evidence
- ORD record
- ord-ef2f3a1ebf1c4899b9bf76d5b0421dab
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504429B2
Reaction notes
Loading…