Bromine → HCID 57431966, compound

HRID 1785196Notes

Reaction equation

HRID 1785196 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].[Br:15]Br>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([Br:15])[CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24408BromineHCID 13187337Ethyl 2-(4-hydroxyphenoxy)acetate

Product 1

HCID 57431966HCID 57431966, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of (4-hydroxy-phenoxy)-acetic acid ethyl ester (0.59 g, 3 mmol) in acetic acid (1.5 mL) is added bromine (0.48 g, 9 mmol) in acetic acid (0.5 mL) at room temperature. After 5 min, solvent is evaporated and purified by column chromatography on silica gel giving the title compound (0.6 g).

Workup

  1. customsolvent is evaporated
  2. custompurified by column chromatography on silica gel giving the title compound (0.6 g)

Sources & evidence

ORD record
ord-2996f51cb4824f62892a991a94ea41bc
Source dataset
uspto-grants-2009_03
Patent number
US07504433B2

Reaction notes

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