反应详情

To a mixture of (4-chlorosulfonyl-phenoxy)-acetic acid ethyl ester (0.98 g, 3.5 mmol) and tin powder (2.1 g) in ethanol (4.4 mL) is added HCl in dioxane (1.0 M, 4.4 mL) under nitrogen. The mixture is heated to reflux for 2 hrs, it is poured into ice and methylene chloride and filtered. The layers are separated and extracted with methylene chloride, dried and concentrated. The crude product is used for next step without purification.

1. temperatureThe mixture is heated
2. temperatureto reflux for 2 hrs
3. filtrationfiltered
4. customThe layers are separated
5. extractionextracted with methylene chloride
6. customdried
7. concentrationconcentrated
8. customThe crude product is used for next step without purification