反应详情

To a solution of 3-Isopropenyl-5-(4-trifluoromethyl-phenyl)-thiophene-2-carbaldehyde (0.084 g, 0.283 mmole) in THF (3 mL), is added to NaBH4 (0.023 g, 0.622 mmole) in one portion at 0° C. The reaction is kept at 0° C. for 15 minutes and warmed up to room temperature for 2 hours. The reaction is quenched using saturated NH4Cl(aq) (20 mL) at 0° C. The THF is removed on rota vapor, the aqueous solution is then extracted with ethyl acetate (2×10 mL). The combined organic solution is washed with brine (3×20 mL), dried over Na2SO4 and concentrated to provide the titled compound as yellow solid, which is used for the next step without further purification.

1. customThe reaction is quenched
2. customat 0° C
3. customThe THF is removed on rota vapor
4. extractionthe aqueous solution is then extracted with ethyl acetate (2×10 mL)
5. washThe combined organic solution is washed with brine (3×20 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated