[3-Isopropenyl-5-(4-trifluoromethyl-phenyl)-thiophen-2-yl]-methanol → HCID 57594995, compound

HRID 1785225Notes

Reaction equation

HRID 1785225 reaction equation
[C:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[S:6][C:5]=1[CH2:19][OH:20])([CH3:3])=[CH2:2]>[Pd]>[CH:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][CH:10]=2)[S:6][C:5]=1[CH2:19][OH:20])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 68853480[3-Isopropenyl-5-(4-trifluoromethyl-phenyl)-thiophen-2-yl]-methanol

Product 1

HCID 57594995HCID 57594995, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The solution of [3-Isopropenyl-5-(4-trifluoromethyl-phenyl)-thiophen-2-yl]-methanol (0.084 g, 0.282 mmole) is stirred under nitrogen gas in presence of 10% palladium on carbon (0.085 g) for 16 hours. The catalyst is removed by filtration, and the filtrate is concentrated to provide the titled compound as white solid, which is used for the next step without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-c911797e2cd04532ac685195fda962e8
Source dataset
uspto-grants-2009_03
Patent number
US07504433B2

Reaction notes

Loading…