反应详情

3-{2-Methyl-4-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethoxy]-phenyl}-propionic acid methyl ester (0.170 g, 0.390 mmole) is treated with a mixture of NaOH(aq) (1 mL)/THF (3 mL)/MeOH (3 mL) at room temperature overnight. The organic solvents are removed on rota-vapor. The residue is diluted with water (10 mL), acidified to pH=2 with 6N HCl(aq). The precipitate is collected through filtration, washed with cold water (30 mL) and dried to provide the titled compound as white solid. MS (ES):419 (M+H)−, the structure is also confirmed by proton NMR.

1. customThe organic solvents are removed on rota-vapor
2. additionThe residue is diluted with water (10 mL)
3. filtrationThe precipitate is collected through filtration
4. washwashed with cold water (30 mL)
5. customdried