Phenethylamine → HCID 57593146, compound

HRID 1785421Notes

Reaction equation

HRID 1785421 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:16]3=[N:17][C:18]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[C:19]([N+:22]([O-:24])=[O:23])[C:20](=[O:21])[N:15]3[CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH2:31]([NH2:39])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>ClCCl>[N+:22]([C:19]1[C:20](=[O:21])[N:15]2[CH2:14][CH2:13][CH2:12][N:11]([C:9]3[CH:8]=[CH:7][N:6]=[C:5]([NH:39][CH2:31][CH2:32][C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[N:10]=3)[C:16]2=[N:17][C:18]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 57593145HCID 57593145, compound

Product 1

HCID 57593146HCID 57593146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 9-(2-methanesulfonyl-pyrimidin-4-yl) -3-nitro-2-phenyl -6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one (220 mg, 0.51 mmol) and phenethylamine (0.13 mL, 1.0 mmol) in dichloromethane (2 mL) was heated to 80° C. for 1 h. Residue purified on silica, and final product isolated as a white solid. M+1=470.

Workup

  1. customResidue purified on silica, and final product
  2. customisolated as a white solid

Sources & evidence

ORD record
ord-fad58e800c124a41a2a52f05347cd69b
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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