[2-(3-Cyano-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester → 3-(2-Amino-propyl)-benzonitrile

Beteiligte Stoffe

Reaktionsschritte

A solution of [2-(3-Cyano-phenyl) -1-methyl-ethyl]-carbamic acid tert-butyl ester (180 mg, 0.69 mmol) in dichloromethane (5 mL) and trifluoroacetic acid (5 mL) was stirred for 15 min at room temperature. Solvents removed under vacuum, and residue was partitioned between dichloromethane and 1 N sodium hydroxide. Organic dried over magnesium sulfate and reduced to an oil under vacuum. M+1=161.

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