Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzophenone imine → HCID 86600374, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzophenone imine | HCID 136809 | — |
| 반응물 | Bis(diphenylphosphino)-1,1'-binaphthyl | HCID 18630801 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 반응물 | tert-butyl N-[1-(3-bromophenyl)propan-2-yl]carbamate | HCID 69066642 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | HCID 86600374 | HCID 86600374 | — |
반응 단계
A suspension of [2-(3-bromo-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (750 mg, 2.39 mmol), benzophenone imine (0.44 mL, 2.63 mmol), sodium tert-butoxide (298 mg, 3.1 mmol), bis(diphenylphosphino)-1,1′-binaphthyl (45 mg, 0.07 mmol), palladium acetate (16 mg, 0.07 mmol), and toluene (7.5 mL) was heated to reflux for 3 h while stirring under an atmosphere of nitrogen. Reaction diluted with ether and organics washed with water and saturated sodium chloride. Product isolated as a viscous yellow oil after purification on silica. M+1=415.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07504403B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-56f42368a1034a21b636a99b3922ec7e |
| 출처 메모 | uspto-grants-2009_03 |