反应详情

A suspension of [2-(3-bromo-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (750 mg, 2.39 mmol), benzophenone imine (0.44 mL, 2.63 mmol), sodium tert-butoxide (298 mg, 3.1 mmol), bis(diphenylphosphino)-1,1′-binaphthyl (45 mg, 0.07 mmol), palladium acetate (16 mg, 0.07 mmol), and toluene (7.5 mL) was heated to reflux for 3 h while stirring under an atmosphere of nitrogen. Reaction diluted with ether and organics washed with water and saturated sodium chloride. Product isolated as a viscous yellow oil after purification on silica. M+1=415.

1. temperaturewas heated
2. temperatureto reflux for 3 h
3. customReaction
4. washorganics washed with water and saturated sodium chloride
5. customProduct isolated as a viscous yellow oil
6. customafter purification on silica