Lithium Hydroxide → HCID 11283352, compound

Participants

Reaction Steps

A solution of 3-[6-oxo-1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a]pyrimidin-3-yl]-propionic acid ethyl ester (240 mg, 0.46 mmol), 10% aqueous lithium hydroxide (0.2 mL), and tetrahydrofuran (5 mL) was heated to 50° C. Reaction partitioned between dichloromethane (50 mL) and 5% sodium dihydrogenphosphate. Organic dried over magnesium sulfate, then concentrated to a white solid under vacuum. M+1=497.

Provenance & Evidence