Lithium Hydroxide → HCID 11283352, compound

HRID 1785437Notes

Reaction equation

HRID 1785437 reaction equation
C([O:3][C:4](=[O:39])[CH2:5][CH2:6][CH:7]1[CH2:12][N:11]2[C:13](=[O:23])[CH:14]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:16]=[C:10]2[N:9]([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:25]=2)[CH2:8]1)C.[OH-].[Li+]>O1CCCC1>[O:23]=[C:13]1[N:11]2[CH2:12][CH:7]([CH2:6][CH2:5][C:4]([OH:39])=[O:3])[CH2:8][N:9]([C:24]3[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[N:25]=3)[C:10]2=[N:16][C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:14]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 11191680HCID 11191680, compound

Product 1

HCID 11283352HCID 11283352, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-[6-oxo-1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a]pyrimidin-3-yl]-propionic acid ethyl ester (240 mg, 0.46 mmol), 10% aqueous lithium hydroxide (0.2 mL), and tetrahydrofuran (5 mL) was heated to 50° C. Reaction partitioned between dichloromethane (50 mL) and 5% sodium dihydrogenphosphate. Organic dried over magnesium sulfate, then concentrated to a white solid under vacuum. M+1=497.

Workup

  1. customReaction
  2. custompartitioned between dichloromethane (50 mL) and 5% sodium dihydrogenphosphate
  3. dry with materialOrganic dried over magnesium sulfate
  4. concentrationconcentrated to a white solid under vacuum

Sources & evidence

ORD record
ord-c4a63c857a0149238c90e001ea0ed467
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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