Magnesium → 3-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1785455Notes

Reaction equation

HRID 1785455 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]([CH3:16])=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:14])[CH3:13])[CH:7]=1.[Mg]>CO>[CH3:1][O:2][C:3](=[O:17])[CH:4]([CH3:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:13])[CH3:14])[CH:7]=1

Participants

4

Reactant 2

HCID 5462224MagnesiumHCID 690673703-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester

Product 1

HCID 575931893-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of 3-[3-(1-amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester (2.0 g, 8.6 mmol), magnesium (0.63 g, 25.8 mmol) in methanol was heated to reflux for 3 h until the starting material was consumed. The mixture was brought to room temperature, filtered and the filtrate was concentrated. The residue obtained was washed with saturated NH4Cl, brine, dried over magnesium sulfate and concentrated.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 h until the starting material
  3. customwas consumed
  4. customwas brought to room temperature
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated
  7. customThe residue obtained
  8. washwas washed with saturated NH4Cl, brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

Sources & evidence

ORD record
ord-69ee3bd99eda4cc58d6d1e27af82a7af
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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