反应详情

温度

70 °C

To a mixture of 8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one (1.86 g, 8.23 mmol), sodium tert-butoxide (1.6 g, 16 mmol), BINAP (0.15 g, 0.207 mmol), and Pd (OAc)2 (55 mg, 0.2 mmol) was added toluene (20 mL) and 4-chloro -2-methylthiopyrimidine (1.5 mL, 12 mmol). After purged with N2 for 10 min, the overall mixture was heated at 70° C. for 3 h prior to being cooled to room temperature. The resulting material was diluted with saturated NHCl(aq), water, and DCM. The organic layer was taken and the aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtrated, and concentrated. Column chromatographic purification (3% MeOH in DCM) of the crude residue afforded the title compound as a yellow solid. MS m/e 351 (M+H)+.

1. customAfter purged with N2 for 10 min
2. temperatureto being cooled to room temperature
3. additionThe resulting material was diluted with saturated NHCl(aq), water, and DCM
4. extractionthe aqueous layer was extracted with DCM
5. dry with materialThe combined organic layers were dried over Na2SO4
6. filtrationfiltrated
7. concentrationconcentrated
8. customColumn chromatographic purification (3% MeOH in DCM) of the crude residue