1-(2-Phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one → HCID 11465507, compound

HRID 1785470Notes

Reaction equation

HRID 1785470 reaction equation
C(N[C:10]1[N:15]=[C:14]([N:16]2[CH2:21][CH2:20][CH2:19][N:18]3[C:22](=[O:32])[CH:23]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:25]=[C:17]23)[CH:13]=[CH:12][N:11]=1)CC1C=CC=CC=1.[NH2:33][CH:34]([CH3:44])[CH2:35][C:36]1[CH:37]=[C:38]([CH2:42][OH:43])[CH:39]=[CH:40][CH:41]=1>>[OH:43][CH2:42][C:38]1[CH:37]=[C:36]([CH2:35][CH:34]([NH:33][C:10]2[N:15]=[C:14]([N:16]3[CH2:21][CH2:20][CH2:19][N:18]4[C:22](=[O:32])[CH:23]=[C:24]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[CH:25]=[C:17]34)[CH:13]=[CH:12][N:11]=2)[CH3:44])[CH:41]=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 112123971-(2-Phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-oneHCID 24721512HCID 24721512, compound

Product 1

HCID 11465507HCID 11465507, compound

Procedure

Following the same procedure described for the synthesis of 1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl -1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one, the sulfoxide (0.29 g, 0.83 mmol) was displaced with [3-(2-amino-propyl)-phenyl]-methanol (0.3 g, 1.66 mmol) to give the title compound as a light yellow solid. MS m/e 468 (M+H)+.

Sources & evidence

ORD record
ord-ad8f2b2f8d6f40b8b539a6bde61a85d7
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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