8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → HCID 11964317, compound

HRID 1785563Notes

Reaction equation

HRID 1785563 reaction equation
[C:1]([C:5]1[O:9][C:8]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:20]=2[CH2:19][C:18](=[O:21])[CH2:17][CH2:16]3)=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C1C=CC(C2OC(NC3C=CC=C4C=3CC(=O)CC4)=NC=2)=CC=1>>[C:1]([C:5]1[O:9][C:8]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:20]=2[CH2:19][CH:18]([OH:21])[CH2:17][CH2:16]3)=[N:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 11964315HCID 11964315, compound

Product 1

HCID 11964317HCID 11964317, compound

Procedure

The title compound was prepared using the procedure as described in Example 2, substituting the product of Example 17C for the product of Example 1I. 1H NMR (DMSO-d6) δ 8.66 (s, 1H), 7.53 (d, J=7.8 Hz, 1H), 7.01 (t, J=7.8 Hz, 1H), 6.75 (d, J=7.5 Hz, 1H), 6.44 (s, 1H), 4.76 (d, J=3.7 Hz, 1H), 3.94 (m, 1H), 2.61-2.99 (m, 4H), 1.84 (m, 1H), 1.60 (m, 1H), 1.22 (s, 9H); MS (ESI+) m/z 287 (M+H)+.

Sources & evidence

ORD record
ord-c7fa47d9c0bd4364964ee29cc9ebb1e2
Source dataset
uspto-grants-2009_03
Patent number
US07504520B2

Reaction notes

Loading…