反应详情

{2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethoxy}-acetic acid ethyl ester was dissolved in tetrahydrofuran at room temperature under nitrogen atmosphere. Lithium aluminium hydride was added to the solution in small portions until the reduction reaction was complete. The reaction was quenched with saturated aqueous ammonium chloride solution. The product was extracted into toluene, which was dried and evaporated in vacuo. The residue was purified with flash chromatography with toluene/triethyl amine (9.5:0.5) as eluent. Yield 68%.

1. customThe reaction was quenched with saturated aqueous ammonium chloride solution
2. extractionThe product was extracted into toluene, which
3. customwas dried
4. customevaporated in vacuo
5. customThe residue was purified with flash chromatography with toluene/triethyl amine (9.5:0.5) as eluent