4,4'-Dichlorobenzhydrol → 1-Benzhydryl-3-(4,4'-dichlorobenzhydryloxy)azetidine

HRID 1785635Notes

Reaction equation

HRID 1785635 reaction equation
C(N1CC(O)C1)(C1C=CC=CC=1)C1C=CC=CC=1.ClC1C=CC(C(O)C2C=CC(Cl)=CC=2)=CC=1.[CH:35]([N:48]1[CH2:51][CH:50]([O:52][CH:53]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[CH:64][CH:63]=2)[C:54]2[CH:59]=[CH:58][C:57]([Cl:60])=[CH:56][C:55]=2Cl)[CH2:49]1)([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH:35]([N:48]1[CH2:51][CH:50]([O:52][CH:53]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[CH:64][CH:63]=2)[C:54]2[CH:59]=[CH:58][C:57]([Cl:60])=[CH:56][CH:55]=2)[CH2:49]1)([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 70334,4'-DichlorobenzhydrolHCID 3304481-(Diphenylmethyl)azetidin-3-olHCID 689038181-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidine

Product 1

HCID 689032041-Benzhydryl-3-(4,4'-dichlorobenzhydryloxy)azetidine

Procedure

This material was prepared from 1-benzhydryl-3-azetidinol (1) (45.0 mmol) and 4,4′-dichlorobenzhydrol (90.0 mmol) using the procedure described for compound (3) (8.6 g, 40%).

Sources & evidence

ORD record
ord-9f45a528f3874963b37c93c375f2c487
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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