1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine

HRID 1785658Notes

Reaction equation

HRID 1785658 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:37])([F:36])[C:21]1[CH:34]=[C:33](Cl)[CH:32]=[CH:31][C:22]=1[CH:23](O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC([Cl:63])=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][CH:16]([O:18][CH:23]([C:24]2[CH:29]=[CH:28][C:27]([Cl:63])=[CH:26][CH:25]=2)[C:22]2[CH:31]=[CH:32][CH:33]=[CH:34][C:21]=2[C:20]([F:37])([F:36])[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 3304481-(Diphenylmethyl)azetidin-3-olHCID 689038181-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanol

Product 1

HCID 689061381-Benzhydryl-3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine

Procedure

This material was prepared from 1-benzhydryl-3-azetidinol (1) (40.1 mmol) and 2-(trifluoromethyl)-4-chlorobenzhydrol (96) (80.2 mmol) using the procedure described for compound (3) (13.5 g, 66%).

Sources & evidence

ORD record
ord-7926ca6fc3d9498facf261d4dc6ee5a1
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

Loading…