Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785658Generated: October 30, 2026

1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine

https://huagongshe.com/reaction/1785658

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
Reactant(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 68907806—
Product1-Benzhydryl-3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]azetidineHCID 68906138—

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (40.1 mmol) and 2-(trifluoromethyl)-4-chlorobenzhydrol (96) (80.2 mmol) using the procedure described for compound (3) (13.5 g, 66%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-7926ca6fc3d9498facf261d4dc6ee5a1
Source noteuspto-grants-2009_03