tert-Butyl isocyanate → 3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide

HRID 1785660Notes

Reaction equation

HRID 1785660 reaction equation
Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[C:25]([N:29]=[C:30]=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:30]([NH:29][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:31])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 689024633-[2-(Trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine hydrochloride

Product 1

HCID 689024133-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-chlorobenzhydryloxy]azetidine hydrochloride (98) (1.32 mmol) and tert-butyl isocyanate (1.32 mmol) using the procedure described for compound (10) (474 mg, 81%).

Sources & evidence

ORD record
ord-410c892c623047be80bc50bf5cc8f433
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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