HRID1785666

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID330448

1-(Diphenylmethyl)azetidin-3-ol

C16H17NO

HCID63895852

未命名化合物

结构：Clc1ccc(C(OC2CN(C(c3ccccc3)c3ccccc3)C2)c2ccc(Cl)cc2Cl)cc1

HCID68903818

未命名化合物

PRODUCTS

生成物

结构：Fc1cc(Br)ccc1C(OC1CN(C(c2ccccc2)c2ccccc2)C1)c1ccccc1C(F)(F)F

HCID68902489

未命名化合物

PROCEDURE

实验过程

This material was prepared from 1-benzhydryl-3-azetidinol (1) (23.0 mmol) and 2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydrol (112) (34.0 mmol) using the procedure described for compound (3) (8.84 g, 67%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cd7aadbfffaf4ab4ad169f7e87f3e4f5
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07504522B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH:1]([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:38])([F:37])[C:21]1[CH:36]=[CH:35][CH:34]=[CH:33][C:22]=1[CH:23](O)[C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][C:25]=1[F:31].C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC(Cl)=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][CH:16]([O:18][CH:23]([C:24]2[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][C:25]=2[F:31])[C:22]2[CH:33]=[CH:34][CH:35]=[CH:36][C:21]=2[C:20]([F:38])([F:37])[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1