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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785666Generated: November 1, 2026

1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-2'-fluoro-4'-bromo-benzhydryloxy]azetidine

https://huagongshe.com/reaction/1785666

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactant2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydrolHCID 63895852—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
Product1-Benzhydryl-3-[2-(trifluoromethyl)-2'-fluoro-4'-bromo-benzhydryloxy]azetidineHCID 68902489—

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (23.0 mmol) and 2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydrol (112) (34.0 mmol) using the procedure described for compound (3) (8.84 g, 67%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-cd7aadbfffaf4ab4ad169f7e87f3e4f5
Source noteuspto-grants-2009_03