3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]azetidine hydrochloride
Reaction equation
C([N:14]1[CH2:17][CH:16]([O:18][CH:19]([C:30]2[CH:35]=[CH:34][C:33]([Br:36])=[CH:32][C:31]=2[F:37])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.[Cl:39]C1C=CC=CC=1C(OC1CNC1)C1C=CC(Cl)=CC=1>>[ClH:39].[F:29][C:26]([F:27])([F:28])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[CH:19]([O:18][CH:16]1[CH2:17][NH:14][CH2:15]1)[C:30]1[CH:35]=[CH:34][C:33]([Br:36])=[CH:32][C:31]=1[F:37]Participants
3
Procedure
This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydryloxy]azetidine (113) (15 mmol) using the procedure described for compound (9) (2.26 g, 51%).
Sources & evidence
- ORD record
- ord-2def2ccb294148af8422d036be79e969
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504522B2
Reaction notes
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