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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785667Generated: October 31, 2026

3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]azetidine hydrochloride

https://huagongshe.com/reaction/1785667

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochlorideHCID 68902343—
Reactant1-Benzhydryl-3-[2-(trifluoromethyl)-2'-fluoro-4'-bromo-benzhydryloxy]azetidineHCID 68902489—
Product3-[2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]azetidine hydrochlorideHCID 86611159—

Reaction Steps

This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydryloxy]azetidine (113) (15 mmol) using the procedure described for compound (9) (2.26 g, 51%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-2def2ccb294148af8422d036be79e969
Source noteuspto-grants-2009_03