tert-Butyl isocyanate → 3-[2-(trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide
Reaction equation
Cl.[F:2][C:3]([F:25])([F:24])[C:4]1[CH:23]=[CH:22][CH:21]=[CH:20][C:5]=1[CH:6]([O:15][CH:16]1[CH2:19][NH:18][CH2:17]1)[C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][C:8]=1[F:14].[C:26]([N:30]=[C:31]=[O:32])([CH3:29])([CH3:28])[CH3:27].ClC1C=C(Cl)C=CC=1C(OC1CN(C(NC(C)(C)C)=O)C1)C1C=CC(Cl)=CC=1>>[F:25][C:3]([F:2])([F:24])[C:4]1[CH:23]=[CH:22][CH:21]=[CH:20][C:5]=1[CH:6]([O:15][CH:16]1[CH2:19][N:18]([C:31]([NH:30][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:32])[CH2:17]1)[C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][C:8]=1[F:14]Participants
4
Reactant 3
Product 1
Procedure
This material was prepared from 3-[2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydryloxy]azetidine hydrochloride (114) and tert-butyl isocyanate (4.54 mmol) using the procedure described for compound (5) (1.33 g, 58%).
Sources & evidence
- ORD record
- ord-9f26d2ec1e7e443488ecf86396c09bc3
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504522B2
Reaction notes
Loading…