Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785668Generated: October 31, 2026

tert-Butyl isocyanate → 3-[2-(trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide

https://huagongshe.com/reaction/1785668

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl isocyanateHCID 62412—
Reactant3-(2,4,4'-trichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamideHCID 11442077—
Reactant3-[2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]azetidine hydrochlorideHCID 86611159—
Product3-[2-(trifluoromethyl)-2'-fluoro-4'-bromobenzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamideHCID 9935850—

Reaction Steps

This material was prepared from 3-[2-(trifluoromethyl)-2′-fluoro-4′-bromobenzhydryloxy]azetidine hydrochloride (114) and tert-butyl isocyanate (4.54 mmol) using the procedure described for compound (5) (1.33 g, 58%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-9f26d2ec1e7e443488ecf86396c09bc3
Source noteuspto-grants-2009_03