4-(Methylthio)benzaldehyde → 2-(Trifluoromethyl)-4'-(methylthio)benzhydrol

HRID 1785669Notes

Reaction equation

HRID 1785669 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[CH3:13][S:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][CH:16]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:19]([OH:20])[C:18]1[CH:21]=[CH:22][C:15]([S:14][CH3:13])=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 769854-(Methylthio)benzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, compound

Product 1

HCID 499629782-(Trifluoromethyl)-4'-(methylthio)benzhydrol

Procedure

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (32 mmol) and 4-(methylthio)benzaldehyde (30 mmol) using the procedure described for compound (96) (9.4 g, 100%).

Sources & evidence

ORD record
ord-5f98a6e397b64cbb9a2ba9d641d66853
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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