Benzaldehyde → 2-(Trifluoromethyl)benzhydrol

HRID 1785682Notes

Reaction equation

HRID 1785682 reaction equation
FC(F)(F)C1C=CC=CC=1[Mg]Br.C(=O)C1C=CC=CC=1.[F:21][C:22]([F:39])([F:38])[C:23]1[CH:36]=[C:35](Cl)[CH:34]=[CH:33][C:24]=1[CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:21][C:22]([F:38])([F:39])[C:23]1[CH:36]=[CH:35][CH:34]=[CH:33][C:24]=1[CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, compound

Product 1

HCID 27774012-(Trifluoromethyl)benzhydrol

Procedure

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and benzaldehyde (15 mmol) using the procedure described for compound (96) (3.7 g, 98%).

Sources & evidence

ORD record
ord-db6a438c9bdf4143a6b901f9fb01f42c
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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