Carbonate Ion → 3-[2-(trifluoromethyl)benzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide

HRID 1785685Notes

Reaction equation

HRID 1785685 reaction equation
Cl.[F:2][C:3]([F:23])([F:22])[C:4]1[CH:21]=[CH:20][CH:19]=[CH:18][C:5]=1[CH:6]([O:13][CH:14]1[CH2:17][NH:16][CH2:15]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:24]([N:28]=[C:29]=[O:30])([CH3:27])([CH3:26])[CH3:25].C(=O)([O-])[O-]>>[F:23][C:3]([F:2])([F:22])[C:4]1[CH:21]=[CH:20][CH:19]=[CH:18][C:5]=1[CH:6]([O:13][CH:14]1[CH2:17][N:16]([C:29]([NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:30])[CH2:15]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 19660Carbonate IonHCID 62412tert-Butyl isocyanateHCID 689051203-[2-(Trifluoromethyl)benzhydryloxy]azetidine hydrochloride

Product 1

HCID 112926733-[2-(trifluoromethyl)benzhydryloxy]-N-(tert-butyl)azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-(trifluoromethyl)benzhydryloxy]azetidine hydrochloride (133) (0.33 mmol), tert-butyl isocyanate (0.33 mmol) and MP-carbonate (2.62 mmol/g, 0.98 mmol) using the procedure described for compound (10) (99.5 mg, 75%).

Sources & evidence

ORD record
ord-123aacc6a11444e495e5ac92cd1cec67
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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