1-Isocyanatoadamantane → 3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(1-adamantyl)-azetidine-1-carboxamide

HRID 1785693Notes

Reaction equation

HRID 1785693 reaction equation
Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[C:25]12([N:35]=[C:36]=[O:37])[CH2:34][CH:29]3[CH2:30][CH:31]([CH2:33][CH:27]([CH2:28]3)[CH2:26]1)[CH2:32]2>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:36]([NH:35][C:25]23[CH2:34][CH:29]4[CH2:28][CH:27]([CH2:33][CH:31]([CH2:30]4)[CH2:32]2)[CH2:26]3)=[O:37])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 20599951-IsocyanatoadamantaneHCID 689024633-[2-(Trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine hydrochloride

Product 1

HCID 113528923-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(1-adamantyl)-azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-chlorobenzhydryloxy]azetidine hydrochloride (98) (0.55 mmol) and 1-adamantyl isocyanate (0.55 mmol) using the procedure described for compound (10) (229 mg, 83%).

Sources & evidence

ORD record
ord-88aa605bfaa34ffaa7e065fa82d621b9
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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