Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785693Generated: October 30, 2026

1-Isocyanatoadamantane → 3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(1-adamantyl)-azetidine-1-carboxamide

https://huagongshe.com/reaction/1785693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-IsocyanatoadamantaneHCID 2059995—
Reactant3-[2-(Trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine hydrochlorideHCID 68902463—
Product3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(1-adamantyl)-azetidine-1-carboxamideHCID 11352892—

Reaction Steps

This material was prepared from 3-[2-(trifluoromethyl)-4′-chlorobenzhydryloxy]azetidine hydrochloride (98) (0.55 mmol) and 1-adamantyl isocyanate (0.55 mmol) using the procedure described for compound (10) (229 mg, 83%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-88aa605bfaa34ffaa7e065fa82d621b9
Source noteuspto-grants-2009_03