4-Methylbenzaldehyde → p-Tolyl(2-(trifluoromethyl)phenyl)methanol

HRID 1785695Notes

Reaction equation

HRID 1785695 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[C:13]1([CH3:21])[CH:18]=[CH:17][C:16]([CH:19]=[O:20])=[CH:15][CH:14]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:19]([OH:20])[C:16]1[CH:17]=[CH:18][C:13]([CH3:21])=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 77254-MethylbenzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, compound

Product 1

HCID 13309099p-Tolyl(2-(trifluoromethyl)phenyl)methanol

Procedure

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and p-tolualdehyde (1.82 mL, 15 mmol) using the procedure described for compound (96) (4.28 g, 100%).

Sources & evidence

ORD record
ord-d05f8651193c4d94b238cc07cd1ed39b
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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