Cyclohexyl isocyanate → 3-[2-(trifluoromethyl)-4'-methylbenzhydryloxy]-N-(cyclohexyl)-azetidine-1-carboxamide

HRID 1785700Notes

Reaction equation

HRID 1785700 reaction equation
Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:32]([NH:31][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:33])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 68902478HCID 68902478, compound

Product 1

HCID 112361903-[2-(trifluoromethyl)-4'-methylbenzhydryloxy]-N-(cyclohexyl)-azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-methylbenzhydryloxy]azetidine hydrochloride (151) (0.56 mmol) and cyclohexyl isocyanate (0.56 mmol) using the procedure described for compound (10). The desired product was obtained as a white foam (230 mg, 91%).

Sources & evidence

ORD record
ord-f98df0d88a7b4901896dc65308b2eb5a
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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