3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → HCID 68903848, compound

HRID 1785703Notes

Reaction equation

HRID 1785703 reaction equation
C([N:14]1[CH2:17][CH:16]([O:18][CH:19]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.ClC1C=CC=CC=1C(OC1CNC1)C1C=CC(Cl)=CC=1>>[F:29][C:26]([F:27])([F:28])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[CH:19]([O:18][CH:16]1[CH2:17][NH:14][CH2:15]1)[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 689023433-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochlorideHCID 689768581-Benzhydryl-3-[2-(trifluoromethyl)-4'-methoxybenz-hydryloxy]azetidine

Product 1

HCID 68903848HCID 68903848, compoundYield 29%

Procedure

The corresponding hydrochloride salt was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4′-methoxybenzyloxy]azetidine (156) (7.5 mmol) using the procedure described for compound (9). Due to the presence of impurities, the salt was partitioned between aqueous base and an organic solvent, the organic phase dried (MgSO4) and evaporated to afford the desired product as a colourless oil (730 mg, 29%).

Workup

  1. customDue to the presence of impurities, the salt was partitioned between aqueous base
  2. dry with materialan organic solvent, the organic phase dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-29fbae571dc042378fa8c5b38c6fe6b3
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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