3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-4'-methoxybenzhydryloxy]azetidine

Participants

Reaction Steps

The corresponding hydrochloride salt was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4′-methoxybenzyloxy]azetidine (156) (7.5 mmol) using the procedure described for compound (9). Due to the presence of impurities, the salt was partitioned between aqueous base and an organic solvent, the organic phase dried (MgSO4) and evaporated to afford the desired product as a colourless oil (730 mg, 29%).

Provenance & Evidence